Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders\nand inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the\ncurrent work is to evaluate its benefits and phytochemicals related to those beneficial properties. A distinct polyphenol profile\nbetween P. tridentatum and M. pulegium was found. Taxifolin, myricetin, ginestin, ginestein, and ginestein derivatives, biochanin\nA-glucoside, and biochanin A were identified in P. tridentatum, whilst in M. pulegium the luteolin-7-rutinoside, diosmin, and\napigenin and respective derivatives were most representative polyphenols. These variations had implications in the antiradical and\nantibacterial activity and the P. tridentatum exhibited the highest antibacterial activity against methicillin-resistant and methicillinsensitive\nStaphylococcus aureus MSSA, which was mainly dose-dependent. This antibacterial activity seems to be related to high\ncontent of flavonols, flavones, and is oflavones, which can act synergistically with each other against this type of bacteria. Our results\nshowed consistent evidence that Pterospartumtridentatumand Mentha pulegium are an important reservoir of phytochemicals with\nantiradical activity and antibacterial capacity and thus they might be used in a preventive way or in a combined pharmaceutical\nand antibiotic therapy against pathogenic bacteria.
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